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Injury prevention formula

Turmeric & glucosamine
Expert opinion

Turmeric & glucosamine

  • Works analgesic and anti-inflammatory
  • Accelerate the healing process in case of injuries
  • Protect the joints, tendons and ligaments
  • Promote the elasticity of cartilage
  • Reducing the wear and tear of cartilage

Glucosamine protects cartilage and reduces pain

Glucosamine is a natural amino saccharide and is used as a building block for the biosynthesis of glycosaminoglycans and hyaluronic acid. Glucosamine has a positive effect on cartilage matrix synthesis, stimulates the metabolism of synovial fibroblasts and reduces the effect of cartilage-destroying enzymes such as metalloproteinases.

The efficacy of glucosamine sulphate (1500 mg/day) in the treatment of joint complaints was confirmed by a Cochrane review. The Cochrane Collaboration carried out a thorough analysis of all available randomised clinical studies addressing the efficacy and safety of various glucosamine preparations in the treatment of osteoarthritis. A total of 25 studies (4,963 patients) were included in the analysis. This Cochrane review shows that glucosamine reduces pain by 22%. Functional well-being was evaluated on the basis of the Lequesne index.

References:
  • Honvo et al. Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. Drugs Aging. 2019 Apr;36(Suppl 1):65-99.
  • Towheed et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005;(2):CD002946.

Turmeric, a natural anti-inflammatory without stomach damage

Clinical research shows that turmeric extracts can improve joint complaints. Turmeric reduces pain and improves mobility. By using turmeric, the use of classic painkillers and anti-inflammatory drugs decreases considerably. Moreover, the long-term use of turmeric does not affect the mucosa of the stomach and intestines. A big advantage compared to anti-inflammatory drugs.

Turmeric is rich in curcuminoids. This biologically active substance influences the production of various inflammatory mediators, among other things. Inhibition of NF-ßB is one of them. This property makes turmeric one of the most powerful natural anti-inflammatory drugs.

The bioavailability after oral administration of curcumin is a problem. One of the solutions is to add black pepper (Piper Nigrum). This solubilisation method also has a positive effect on the effect of turmeric. Black pepper not only improves the absorption of curcuminoids but also increases the duration of action of turmeric. The reason for this? Black pepper reduces the breakdown of curcuminoids by the liver enzymes.

References:
  • Panahi et al. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014 Nov;28(11):1625-31.
  • Henrotin et al. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013 Dec;2(1):56.
  • Madhu et al. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013 Apr;21(2):129-36.
  • Suresh et al. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res. 2010 May;131:682-91.